Search results for "large [Cosmology]"

showing 10 items of 272 documents

Is CD1a involved in antitumour immune responses during carcinogenesis?

2004

Sir, I read with interest the article of Coventry and Morton (2003) that investigated DC infiltration within breast cancers and the association with survival. Interestingly, they found that more patients were alive at the 5-year time point in the group with higher CD1a DC density than the lower CD1a DC group, but this failed to reach statistical significance at the P=0.05 level. In our opinion, the role of CD1 family molecules in antitumour immune responses, and in particular of CD1a, should be more debated, since its expression was recently described not only in monocyte-derived dendritic cells, but also in nonmesenchymal cytotypes, that is, epithelial cells (Ulanova et al, 2000). We recen…

Cancer ResearchPathologymedicine.medical_specialtyCD1Large seriesBiologymedicine.diseasemedicine.disease_causeImmune systemOncologyDysplasiaMetaplasiamedicinemedicine.symptomCarcinogenesisInfiltration (medical)Survival analysisBritish Journal of Cancer
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Radioisotopic determination of l-carnitine content in foods commonly eaten in Western countries

2004

Abstract l -Carnitine is a vitamin-like nutrient essential for energy production and lipid metabolism in many organs and tissues such as skeletal muscle and heart. Even if l -carnitine can be synthesized, most of the carnitine present in human body is provided by food. Until now, no large study has been conducted where the content in l -carnitine of various foods was analyzed. The objective of this study was to determine the level of free l -carnitine present in food commonly consumed in Western countries. A radioisotopic assay was used to estimate l -carnitine content in raw and processed foods. From this study, it clearly appeared that meat products were the best sources for l -carnitine.…

Chemistrybusiness.industryLipid metabolismGeneral MedicineAnalytical ChemistryNutrientFood processingLarge studymedicineFish <Actinopterygii>Food scienceCarnitinebusinessBeta oxidationFood Sciencemedicine.drugFood Chemistry
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Pediatric Anaplastic Large Cell Lymphoma with Concomitant Involvement of Spine and Central Nervous System: A Case Report and Review of Literature

2021

Anaplastic large cell lymphoma (ALCL) is a histological subtype of non-Hodgkin lymphoma, largely characterized by anaplastic lymphoma kinase (ALK) positivity, resulting from the chromosomal translocation t(2;5). We report a pediatric case of ALK-positive ALCL with primary concomitant involvement of bone and central nervous system (CNS); thereafter, a literature review about pediatric primary bone and primary CNS ALCL was conducted. According to the analyzed data, our case is unique because it is characterized by the contemporary involvement of the spine and CNS. During and after chemotherapy, our patient was monitored by detecting minimal residual disease (MRD) through the analysis of fusio…

ChemotherapyPathologymedicine.medical_specialtybusiness.industrymedicine.medical_treatmentRcentral nervous systemmedicine.diseaseboneMinimal residual diseaseLymphomamedicine.anatomical_structureFusion transcriptanaplastic large cell lymphomahemic and lymphatic diseasesConcomitantminimal residual diseasemedicineMedicineAnaplastic lymphoma kinaseBone marrowbusinessAnaplastic large-cell lymphomaHemato
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How consistent are the transcriptome changes associated with cold acclimation in two species of the Drosophila virilis group?

2015

This work was financially support by a Marie Curie Initial Training Network grant, “Understanding the evolutionary origin of biological diversity” (ITN-2008–213780 SPECIATION), grants from the Academy of Finland to A.H. (project 132619) and M.K. (projects 268214 and 272927), a grant from NERC, UK to M.G.R. (grant NE/J020818/1), and NERC, UK PhD studentship to D.J.P. (NE/I528634/1). For many organisms the ability to cold acclimate with the onset of seasonal cold has major implications for their fitness. In insects, where this ability is widespread, the physiological changes associated with increased cold tolerance have been well studied. Despite this, little work has been done to trace chang…

Chill-comaAcclimatizationQH301 BiologyDrosophila virilisStress toleranceGenes Insectta3111AcclimatizationTranscriptomeMyoinositolQH301Species SpecificityCulex-pipiensMelanogasterGeneticsMelanogasterCold acclimationAnimalsThermotaxisCircadian rhythmDifferential expression analysisGeneGenetics (clinical)Northern house mosquitoGeneticsbiologySequence Analysis RNAcold acclimationta1184TemperatureChromosome MappingLarge gene listsbiology.organism_classificationBiological-membranesCold TemperatureDrosophila virilisMultigene Familyta1181Original ArticleDrosophilaFemaleGenetic FitnessTranscriptomeHeredity
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Structure Effect of Imidazolium-Based Dicationic Ionic Liquids on Claisen Rearrangement

2014

A large group of imidazolium-based dicationic ionic liquids (DILs) has been prepared in good yields. Thermal stability of all DILs has been determined. The effects of the reaction time, cation, imidazolium C2–H acidity, and anion on the Claisen rearrangement of allyl phenyl ether have been investigated. Type of anion and the presence of the acidic C2–H bond in the imidazolium moieties have proven to be essential for this reaction. The simple procedure and the possibility of avoiding the use catalysts and volatile organic solvents make this synthetic method environmentally benign and adaptable for large-scale applications.

Claisen rearrangementchemistry.chemical_compoundchemistryOrganic ChemistryIonic liquidOrganic chemistryEtherThermal stabilitySigmatropic reactionLarge groupCatalysisIon
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Identifying individual differences using log-file analysis: Distributed learning as mediator between conscientiousness and exam grades

2018

Abstract Online learning poses major challenges on students' self-regulated learning. This study investigated the role of learning strategies and individual differences in cognitive abilities, high school GPA and conscientiousness for successful online learning. We used longitudinal log-file data to examine learning strategies of a large cohort (N = 424) of university students taking an online class. Distributed learning, the use of self-tests and a better high school GPA was associated with better exam grades. The positive effect of conscientiousness on exam grades was mediated by distributed learning. Conscientious students distributed their studying over the course of the semester, which…

Class (computer programming)Social PsychologyOnline learning05 social sciences050301 education050109 social psychologyConscientiousnessCognitionEducationLarge cohortOnline courseComputingMilieux_COMPUTERSANDEDUCATIONDevelopmental and Educational PsychologyMathematics education0501 psychology and cognitive sciencesDistributed learningPsychology0503 educationPractical implicationsLearning and Individual Differences
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On Fine and Wilf's theorem for bidimensional words

2003

AbstractGeneralizations of Fine and Wilf's Periodicity Theorem are obtained for the case of bidimensional words using geometric arguments. The domains considered constitute a large class of convex subsets of R2 which include most parallelograms. A complete discussion is provided for the parallelogram case.

CombinatoricsLarge classDiscrete mathematicsGeneral Computer ScienceGeneralizationRegular polygonParallelogramWord (group theory)MathematicsTheoretical Computer ScienceComputer Science(all)Theoretical Computer Science
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Learning spatial filters for multispectral image segmentation.

2010

International audience; We present a novel filtering method for multispectral satel- lite image classification. The proposed method learns a set of spatial filters that maximize class separability of binary support vector machine (SVM) through a gradient descent approach. Regularization issues are discussed in detail and a Frobenius-norm regularization is proposed to efficiently exclude uninformative filters coefficients. Experiments car- ried out on multiclass one-against-all classification and tar- get detection show the capabilities of the learned spatial fil- ters.

Computer Science::Machine LearningMultispectral image0211 other engineering and technologies02 engineering and technology01 natural sciencesRegularization (mathematics)010104 statistics & probability[INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG]Life ScienceComputer visionSegmentation0101 mathematicsLarge margin method021101 geological & geomatics engineeringMathematicsImage segmentationContextual image classificationPixelbusiness.industryPattern recognitionImage segmentationSupport vector machineComputingMethodologies_PATTERNRECOGNITIONmultispectral imageSpatial FilteringArtificial intelligenceGradient descentbusiness
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Revenue models, in-app purchase, and the app performance: Evidence from Apple's App Store and Google Play

2016

The effect of revenue models on app performance depends on the app store.The effect of in-app purchase on app performance depends on the app store.Paid, freemium and in-purchase models are shown to be effective in app store.Freemium and in-app purchase models are shown to be less effective in Google Play.App category influences the effects of both revenue models and in-app purchase. In this paper, we empirically examine how the revenue model (paid, free, or freemium) adopted for a given app affects the app revenue performance as measured by the app daily revenue rank. We also study the impact of in-app purchase on this measure of performance. Moreover, we study how such relationships are co…

ComputerSystemsOrganization_COMPUTERSYSTEMIMPLEMENTATIONGeneralLiterature_INTRODUCTORYANDSURVEYComputer Networks and CommunicationsE-commerceApp storeGeneralLiterature_MISCELLANEOUSManagement of Technology and Innovationmental disorders0502 economics and businessRevenueMobile app market Online distribution Revenue model E-commerce Empirical analysis.MarketingMarketingbusiness.industryInformationSystems_INFORMATIONSYSTEMSAPPLICATIONS05 social sciencesAdvertisingSettore ING-IND/35 - Ingegneria Economico-GestionaleFreemiumComputer Science ApplicationsLarge sampleRevenue modelFree model050211 marketingbusiness050203 business & management
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Mechanism of Néel Order Switching in Antiferromagnetic Thin Films Revealed by Magnetotransport and Direct Imaging.

2019

We probe the current-induced magnetic switching of insulating antiferromagnet/heavy metals systems, by electrical spin Hall magnetoresistance measurements and direct imaging, identifying a reversal occurring by domain wall (DW) motion. We observe switching of more than one third of the antiferromagnetic domains by the application of current pulses. Our data reveal two different magnetic switching mechanisms leading together to an efficient switching, namely the spin-current induced effective magnetic anisotropy variation and the action of the spin torque on the DWs.

Condensed Matter - Materials ScienceMaterials scienceMagnetoresistanceCondensed matter physicsMaterials Science (cond-mat.mtrl-sci)FOS: Physical sciencesGeneral Physics and AstronomyLarge scale facilities for research with photons neutrons and ionsDirect imaging01 natural sciences3. Good healthMagnetic anisotropyOrder (biology)Domain wall (magnetism)0103 physical sciencesTorqueAntiferromagnetismCondensed Matter::Strongly Correlated ElectronsThin film010306 general physicsSpin-½Physical Review Letters
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